Reaktion #1781930

ord-58239a4d6a9a4aecbd462b5f965d84e1

Reaktionsgleichung

C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
product
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
2-(2-Borono-4-chlorophenoxy)-(2S)-propanoic acid
CN(C)S(=O)(=O)c1ccc(I)c(Cl)c1
product
CN(C)S(=O)(=O)c1ccc(I)c(Cl)c1
3-Chloro-4-iodo-N,N-dimethylbenzenesulfonamide
→
C[C@H](Oc1ccc(Cl)cc1-c1ccc(S(=O)(=O)N(C)C)cc1Cl)C(=O)O
title compound
C[C@H](Oc1ccc(Cl)cc1-c1ccc(S(=O)(=O)N(C)C)cc1Cl)C(=O)O
[[2′,5-Dichloro-4′-[(dimethylamino)sulfonyl][1,1′-biphenyl]-2-yl]oxy]-(2S)-propanoic acid

Edukte

C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
product
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
2-(2-Borono-4-chlorophenoxy)-(2S)-propanoic acid
CN(C)S(=O)(=O)c1ccc(I)c(Cl)c1
product
CN(C)S(=O)(=O)c1ccc(I)c(Cl)c1
3-Chloro-4-iodo-N,N-dimethylbenzenesulfonamide

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeYield (0.08 g)

Vorschrift

The title compound was prepared by the method of example 144 step (i) using the product from example 151 step (iv), the product from example 148 step (ii) and methanol as solvent. Yield (0.08 g).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08158820B2uspto-grants-2012_04