Reaktion #1780322

Reaktionsgleichung

5-fluoro-3-isobutyl-benzo[b]thiophene-2-sulfonic acid(4-bromo-2-trifluoromethyl-phenyl)-amide

4-pyridineboronic acid

→

title compound

5-Fluoro-3-isobutyl-benzo[b]thiophene-2-sulfonic acid(4-pyridin-4-yl-2-trifluoromethyl-phenyl)-amide

Lösungsmittel

1,2-dimethoxyethane

ethanol

sodium carbonate

Reaktionsbedingungen

Vorschrift

This compound was prepared in analogy to Example 2 starting from 5-fluoro-3-isobutyl-benzo[b]thiophene-2-sulfonic acid(4-bromo-2-trifluoromethyl-phenyl)-amide (0.10 g) and 4-pyridineboronic acid (0.036 g) in 1,2-dimethoxyethane (7 ml), ethanol (1 ml) and 2 molar sodium carbonate (2.0 ml) with tetrakis(triphenylphosphine)palladium (0.027 g) to obtain the title compound (0.47 g) as a yellowish solid. MS (ISN): 507.1 (M−H)−

Quelle