Reaktion #1780320

Reaktionsgleichung

5-fluoro-3-isobutyl-benzo[b]thiophene

chlorosulfonic acid

→

title compound

Ausbeute 60.5%

5-Fluoro-3-isobutyl-benzo[b]thiophene-2-sulfonyl chloride

Ausbeute 60.5%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigequenched with ice/water
2. 2
   Extraktionextracted with methylene chloride
3. 3
   WaschenThe organic phases were washed with water and aqueous sodium bicarbonate solution
4. 4
   Sonstigedried
5. 5
   Einengenconcentrated
6. 6
   SonstigeThe residue was chromatographed on silica gel

Vorschrift

To a solution of 5-fluoro-3-isobutyl-benzo[b]thiophene 0.55 g) in chloroform (10 ml) was added chlorosulfonic acid (1.54 g), and the resulting mixture was stirred at rt for 3 h, quenched with ice/water, and extracted with methylene chloride. The organic phases were washed with water and aqueous sodium bicarbonate solution, dried and concentrated. The residue was chromatographed on silica gel using heptane/ethyl acetate as eluent to obtain the title compound (0.49 g) as a colorless oil. MS (EI): 306.8 (M)

Quelle