Reaktion #1780175

Reaktionsgleichung

2-(methyl-thio)pyrimidine-4(3H)-one

3-(2-methylthiazol-4-yl)benzenamine

→

desired compound

Ausbeute 25.0%

2-(3-(2-methylthiazol-4-yl)phenylamino)pyrimidin-4(3H)-one

Ausbeute 25.0%

Lösungsmittel

diglyme

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe resulting mixture is heated
2. 2
   Temperaturto reflux
3. 3
   WaschenThe solid is washed with hexanes

Vorschrift

To 2-(methyl-thio)pyrimidine-4(3H)-one, 1, (1 g, 14.08 mmol) in diglyme (9 mL) is added 3-(2-methylthiazol-4-yl)benzenamine (3.20 g, 16.90 mmol). The resulting mixture is heated to reflux and stirred for 18 hours. A solid forms upon cooling the mixture to room temperature. The solid is washed with hexanes to afford 1.0 g (25% yield) of the desired compound. MS (ESI, pos. ion) m/z: 285 (M+1).

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