Reaktion #1772026

Reaktionsgleichung

(R)-((S)-1-phenylethyl) 2-(2-fluorophenyl)-2-(piperidin-1-yl)acetate

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title compound

Ausbeute 98.1%

(R)-2-(2-fluorophenyl)-2-(piperidin-1-yl)acetic acid

Ausbeute 98.1%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas hydrogenated at room temperature
2. 2
   SonstigeThe solution was then purged with Ar
3. 3
   Filtrationfiltered through diatomaceous earth (Celite®)
4. 4
   Einengenconcentrated in vacuo

Vorschrift

A mixture of (R)-((S)-1-phenylethyl) 2-(2-fluorophenyl)-2-(piperidin-1-yl)acetate (0.737 g, 2.16 mmol) and 20% Pd(OH)2/C (0.070 g) in ethanol (30 mL) was hydrogenated at room temperature and atmospheric pressure (H2 balloon) for 2 hours. The solution was then purged with Ar, filtered through diatomaceous earth (Celite®), and concentrated in vacuo. This provided the title compound as a colorless solid (0.503 g, 98%). 1H NMR (400 MHz, CD3OD) δ 7.65 (ddd, J=9.1, 7.6, 1.5 Hz, 1H), 7.47-7.53 (m, 1H), 7.21-7.30 (m, 2H), 3.07-3.13 (m, 4H), 1.84 (br s, 4H), 1.62 (br s, 2H). LCMS: Anal. Calcd. for C13H16FNO2: 237. found: 238 (M+H)+.

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