Reaktion #1771991

Reaktionsgleichung

Boc-Pro(4,4-diMe)-OH

thionylchloride

methanol

→

4,4-Dimethylproline Methylester Hydrochloride Salt

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated to an amorphous solid (377 mg, 95%)

Vorschrift

To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).

Quelle