Reaktion #1765251

Reaktionsgleichung

Sodium methoxide

1-(6-chloro-pyridin-3-yl)-propan-1-one

→

product

Ausbeute 77.0%

1-(6-Methoxy-pyridin-3-yl)-propan-1-one

Ausbeute 77.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction mixture was heated
2. 2
   Temperaturunder reflux for eighteen hours
3. 3
   EinengenThe solution was concentrated to fifty percent
4. 4
   workup.ADDITIONdiluted with water (100 mL)
5. 5
   Extraktionextracted with ethyl acetate (2×100 mL)
6. 6
   WaschenThe combined extracts were washed with brine
7. 7
   Trocknendried (Na2SO4)
8. 8
   Einengenconcentrated

Vorschrift

Sodium methoxide (2.8 g, 50 mmol) was added to a solution of 1-(6-chloro-pyridin-3-yl)-propan-1-one (2.8 g, 16.5 mmol) in methanol (70 mL) and the reaction mixture was heated under reflux for eighteen hours. The solution was concentrated to fifty percent, diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The combined extracts were washed with brine, dried (Na2SO4) and concentrated to give product as a colorless oil (2.1 g, 77 percent yield), which was used without further purification.

Quelle