Reaktion #1760747

Reaktionsgleichung

citric acid

tert-butyl 2-(benzamido)-4-bromobenzoate

4-phenylpiperidine

cesium carbonate

2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl

2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl

→

tert-butyl 2-(benzamido)-4-(4-phenylpiperidin-1-yl)benzoate

Lösungsmittel

ethyl acetate

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe resulting mixture was heated
2. 2
   Temperaturto reflux for 2 hours
3. 3
   Temperaturthe resulting mixture was heated
4. 4
   Temperaturto reflux for 6 hours
5. 5
   TemperaturAfter the reaction mixture was cooled to room temperature
6. 6
   SonstigeThe organic layer was separated
7. 7
   Trocknendried over anhydrous magnesium sulfate
8. 8
   Waschenafter washed with a saturated sodium chloride aqueous solution
9. 9
   Sonstigethe solvent was evaporated under reduced pressure
10. 10
    SonstigeThe obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane:ethyl acetate=10:1]

Vorschrift

86 mg of 4-phenylpiperidine, 0.22 g of cesium carbonate, 2.4 mg of tris(dibenzylideneacetone)dipalladium(0), 1.2 mg of palladium acetate and 6.3 mg of 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl were added to 3.0 mL of toluene solution containing 0.10 g of tert-butyl 2-(benzamido)-4-bromobenzoate, and the resulting mixture was heated to reflux for 2 hours. After the reaction mixture was cooled to room temperature, 2.4 mg of tris(dibenzylideneacetone)dipalladium(0), 1.2 mg of palladium acetate and 6.3 mg of 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl were added and the resulting mixture was heated to reflux for 6 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane:ethyl acetate=10:1] to obtain tert-butyl 2-(benzamido)-4-(4-phenylpiperidin-1-yl)benzoate as pale yellow solid.

Quelle