Reaktion #1760278

Reaktionsgleichung

Water

ethyl acetate

1-hydroxyisoquinoline

Bromine

→

title compound

Ausbeute 80.1%

4-Bromo-1-isoquinolinol

Ausbeute 80.1%

Lösungsmittel

tetrahydrofuran

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe resulting reaction mixture
2. 2
   Filtrationwas filtered
3. 3
   Filtrationthrough filter paper
4. 4
   WaschenThe organic layer was washed with saturated brine
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   SonstigeThe residue was recrystallized from ethyl acetate and hexane

Vorschrift

Bromine (1.78 ml, 34.5 mmol) was added to an ice-cooled solution of 1-hydroxyisoquinoline (5.01 g, 34.5 mmol) in acetic acid (50 ml), and this reaction mixture was stirred at room temperature for 2 hours. Water, ethyl acetate, and tetrahydrofuran were added, and the resulting reaction mixture was filtered through filter paper. The organic layer was washed with saturated brine and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate and hexane to give the title compound (6.19 g).

Quelle