Reaktion #1757540

Reaktionsgleichung

1-adamantanecarbonyl chloride

2-bromo-2,2-difluoroethanol

Triethylamine

→

2-bromo-2,2-difluoroethyl 1-adamantanecarboxylate

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturice cooled
2. 2
   workup.DISTILLATIONBy standard separation operation and solvent distillation

Vorschrift

In tetrahydrofuran, 1-adamantanecarbonyl chloride and 2-bromo-2,2-difluoroethanol were mixed and ice cooled. Triethylamine was added to the mixture. By standard separation operation and solvent distillation, 2-bromo-2,2-difluoroethyl 1-adamantanecarboxylate was obtained. This compound was converted into a sodium sulfinate with sodium dithionite and then oxidized with hydrogen peroxide, yielding the target compound, sodium 2-(1-adamantanecarbonyloxy)-1,1-difluoroethane-sulfonate.

Quelle