Reaktion #1757236

Reaktionsgleichung

1-(4-methylphenyl)pyrene

N-bromosuccinimide

dimethylformamide

→

1-bromo-6-(4-methylphenyl)pyrene

Ausbeute 22.4%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter the mixture was cooled to room temperature
2. 2
   Extraktionthe mixture was extracted with 500 ml of dichloromethane
3. 3
   WaschenThe organic layer was washed twice with 200 ml of water
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Filtrationfiltered through celite
6. 6
   SonstigeThe filtrate was evaporated
7. 7
   Waschenthe resulting residue was washed twice with 200 ml of ethyl acetate
8. 8
   SonstigeThe precipitated solid was separated by filtration
9. 9
   Sonstigedried under vacuum

Vorschrift

A mixed solution of 40 g of 1-(4-methylphenyl)pyrene, 24.4 g of N-bromosuccinimide and 1.4 l of dimethylformamide was then heated and stirred at 40° C. for 7 hours under a nitrogen stream. After the mixture was cooled to room temperature, 1 l (liter) of water was added thereto, and the mixture was extracted with 500 ml of dichloromethane. The organic layer was washed twice with 200 ml of water, dried over magnesium sulfate, and then filtered through celite. The filtrate was evaporated, and the resulting residue was washed twice with 200 ml of ethyl acetate. The precipitated solid was separated by filtration and dried under vacuum to give 11.4 g of 1-bromo-6-(4-methylphenyl)pyrene.

Quelle