Reaktion #1756718

Reaktionsgleichung

TFA

intermediate ( 1a )

4′-(2-Butyl-4-chloro-5-formylimidazol-1-ylmethyl)biphenyl-2-sulfonic acid t-butylamide

→

4′-(2-Butyl-4-chloro-5-formylimidazol-1-ylmethyl)biphenyl-2-sulfonic acid amide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTFA was removed under vacuum
2. 2
   workup.WAITGradient conditions: 25% solvent B/75% solvent A to 95% solvent B/5% solvent B over 6 minutes

Vorschrift

C2HF3O2 (1b): TFA (10 mL, 129.8 mmol) was added to intermediate (1a) (5.0 g, 10.2 mmol). The mixture was stirred at 80° C. for 2 hours. TFA was removed under vacuum and the crude intermediate (1b), as a TFA salt, was used in the next step (5.6 g). Anal. HPLC: retention time=3.4 minutes. Gradient conditions: 25% solvent B/75% solvent A to 95% solvent B/5% solvent B over 6 minutes. MS m/z: [M+H]+ calcd for C21H22ClN3O3S, 432.11; found 432.2.

Quelle