Reaktion #1755462

Reaktionsgleichung

2-(3,5-dimethyl-phenyl)-1-thiophen-2-yl-ethylamine

2-(3,5-Dimethyl-phenyl)-1-thien-2-yl-ethylamine

acetic acid 2-isothiocyanato-ethyl ester

→

product

Ausbeute 25.7%

Acetic Acid 2-{3-[2-(3,5-dimethyl-phenyl)-1-thien-2-yl-ethyl]-thioureido}-ethyl Ester

Ausbeute 25.7%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated
2. 2
   Sonstigethe residue purified by column chromatography

Vorschrift

A solution of 2-(3,5-dimethyl-phenyl)-1-thiophen-2-yl-ethylamine (1.4 g, from example 1) and acetic acid 2-isothiocyanato-ethyl ester (0.75 g, prepared according to Collect. Czech. Chem. Commun. 1986, 51, 112-117) in toluene (15 ml) was stirred at room temperature for 12 h, evaporated and the residue purified by column chromatography to yield the product (0.5 g) as a yellowish oil.

Quelle