Reaktion #1755461

Reaktionsgleichung

2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide

hydrogenchloride

→

2-(3,5-Dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethylamine

Ausbeute 77.0%

Lösungsmittel

methanol

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was quenched with aqueous potassium carbonate solution
2. 2
   Extraktionextracted
3. 3
   Trocknenthe organic phases dried over magnesium sulfate
4. 4
   SonstigeAfter evaporation of the solvent a yellowish oil
5. 5
   Sonstigewas obtained in 77% yield (1.05 g)

Vorschrift

A solution of RS 2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide (2.0 g) in methanol (12 ml) was treated with a solution of hydrogenchloride in dioxane (12 ml, 4 N) at room temperature overnight. The reaction mixture was quenched with aqueous potassium carbonate solution and adjusted to pH 8-9, extracted and the organic phases dried over magnesium sulfate. After evaporation of the solvent a yellowish oil was obtained in 77% yield (1.05 g).

Quelle