Reaktion #1755452

Reaktionsgleichung

11-bromoundecanoic acid t-butyl ester

NaNO2

phloroglucinol

→

solid

Ausbeute 42.0%

11-Nitroundecanoic acid tert-butyl ester

Ausbeute 42.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter separation
2. 2
   Extraktionthe aqueous phase was further extracted with PET (3×30 mL)
3. 3
   Trocknendried (Na2SO4)
4. 4
   Einengenconcentrated in vacuo
5. 5
   SonstigeThe crude product was purified by silica-gel column chromatography (PET/diethyl ether 95/5)

Vorschrift

In a 100 ml two-neck round bottom flask 11-bromoundecanoic acid t-butyl ester (6.10 g, 19.0 mmol) was dropped into a stirred solution of NaNO2 (2.60 g, 38.0 mmol) and phloroglucinol (3.10 g, 19.0 mmol) in DMF (10 ml). The reaction mixture was warmed at 50° C. and stirred for 24 h, then poured into a mixture of 40 mL of ice/water and 40 mL of PET. After separation, the aqueous phase was further extracted with PET (3×30 mL), dried (Na2SO4) and concentrated in vacuo. The crude product was purified by silica-gel column chromatography (PET/diethyl ether 95/5) obtaining a light yellow solid (2.29 g, 42%). M.p. 39-42° C. ESI-MS: 288 (MH+); (Calc. for C15H29NO4: 287 u.m.a.).

Quelle