Reaktion #1754833

Reaktionsgleichung

2′-(trifluoromethyl)acetophenone

bromine

→

2-bromo-1-(2-trifluoromethyl-phenyl)-ethanone

Ausbeute 92.8%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA stream of nitrogen was bubbled through the reaction mixture for 15 minutes
2. 2
   SonstigeThe mixture solvent was removed under reduced pressure
3. 3
   workup.DISSOLUTIONThe residue was dissolved with ethanol
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

To a solution of 20.00 g (0.11 mole) of 2′-(trifluoromethyl)acetophenone in 200 mL of dichloromethane was added 5.5 mL (0.11 mole) of bromine over 90 minutes. A stream of nitrogen was bubbled through the reaction mixture for 15 minutes. The mixture solvent was removed under reduced pressure. The residue was dissolved with ethanol, and then concentrated under reduced pressure to give 27.25 g of 2-bromo-1-(2-trifluoromethyl-phenyl)-ethanone as a yellow oil, which was used in the next step without further purification.

Quelle