Reaktion #1753964

Reaktionsgleichung

(3-[1,3]dioxolan-2-ylphenyl)-phenyl-methanol

sodium iodide

dichloromethylsilane

→

title compound

3-Benzylbenzaldehyde

Lösungsmittel

acetonitrile

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwash with water, saturated sodium bicarbonate, 10% sodium thiosulfate
2. 2
   TrocknenDry the organic layers (Na2SO4)
3. 3
   Filtrationfilter
4. 4
   Einengenconcentrate
5. 5
   Sonstigeto give a residue
6. 6
   WaschenChromatograph the residue eluting with 9:1 hexane

Vorschrift

Combine (3-[1,3]dioxolan-2-ylphenyl)-phenyl-methanol (2.3 g, 8.7 mmol) and sodium iodide (5.3 g, 35.0 mmol) in acetonitrile (25 ml). Add dichloromethylsilane (2.1 ml, 17.4 mmol) via syringe. After 10 min, dilute with EtOAc and wash with water, saturated sodium bicarbonate, 10% sodium thiosulfate, and then brine. Dry the organic layers (Na2SO4), filter, and concentrate to give a residue. Chromatograph the residue eluting with 9:1 hexane:EtOAc to give the title compound.

Quelle