Reaktion #1750333

ord-271c68b0bd4446229fa4011e0fceeea4

Reaktionsgleichung

O=C(Oc1c(F)c(F)c(F)c(F)c1F)c1ccccc1NCc1ccncc1
2-[(Pyridin-4-ylmethyl)-amino]-benzoic acid pentafluorophenyl ester
NOCc1ccc(Cl)s1
O-(5-chloro-thiophen-2-ylmethyl)-hydroxylamine
→
O=C(NOCc1ccc(Cl)s1)c1ccccc1NCc1ccncc1
N-(5-Chloro-thiophen-2-ylmethoxy)-2-[(pyridin-4-ylmethyl)-amino]-benzamide

Edukte

O=C(Oc1c(F)c(F)c(F)c(F)c1F)c1ccccc1NCc1ccncc1
2-[(Pyridin-4-ylmethyl)-amino]-benzoic acid pentafluorophenyl ester
NOCc1ccc(Cl)s1
O-(5-chloro-thiophen-2-ylmethyl)-hydroxylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared by the same method

Vorschrift

Prepared by the same method as described for example 415. Starting materials: 2-[(Pyridin-4-ylmethyl)-amino]-benzoic acid pentafluorophenyl ester (preparation 7C) and O-(5-chloro-thiophen-2-ylmethyl)-hydroxylamine (see preparation 64).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08034811B2uspto-grants-2011_10