Reaktion #1748392

ord-1a42cfd2bc1147eaa0188dfcc1acde58

Reaktionsgleichung

CCOC(=O)c1cn(-c2cccc(-c3cccnc3F)c2)cn1
9i
CCOC(=O)c1cn(-c2cccc(-c3cccnc3F)c2)cn1
1-[3-(2-Fluoro-pyridin-3-yl)-phenyl]-1H-imidazole-4-carboxylic acid ethyl ester
[K+].[OH-]
potassium hydroxide
→
O=C(O)c1cn(-c2cccc(-c3cccnc3F)c2)cn1
1-[3-(2-Fluoro-pyridin-3-yl)-phenyl]-1H-imidazole-4-carboxylic acid

Edukte

CCOC(=O)c1cn(-c2cccc(-c3cccnc3F)c2)cn1
9i
CCOC(=O)c1cn(-c2cccc(-c3cccnc3F)c2)cn1
1-[3-(2-Fluoro-pyridin-3-yl)-phenyl]-1H-imidazole-4-carboxylic acid ethyl ester
[K+].[OH-]
potassium hydroxide

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

This compound is prepared by hydrolysis of 9i using a 1:1 mixture of aqueous potassium hydroxide (2M) and ethanol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08030339B2uspto-grants-2011_10