Reaktion #1747866

Reaktionsgleichung

4-iodophenol

benzyl chloride

potassium carbonate

→

4-Iodophenyl benzyl ether

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturto reflux temperature
3. 3
   Temperaturheated
4. 4
   Filtrationthe reaction mixture was filtered
5. 5
   EinengenThe filtrate was concentrated
6. 6
   Temperaturcooled in an ice bath, in the course of which a solid
7. 7
   Sonstigeprecipitated out
8. 8
   SonstigeThis was removed by means of a blue-band filter
9. 9
   Sonstigedried
10. 10
    SonstigeThe crude product (23.22 g) was recrystallized from 70 ml of ethanol
11. 11
    Sonstigean m.p. of 61-62° C. (lit. 62° C.)
12. 12
    Sonstigewere obtained

Vorschrift

A reaction mixture composed of 21.40 g (95.3 mmol) of 98% 4-iodophenol, 12.19 g (95.3 mmol) of 99% benzyl chloride, 20.73 g (150 mmol) of potassium carbonate and 250 ml of acetone was heated to reflux temperature and heated to boiling for 30 hours. After cooling to room temperature, the reaction mixture was filtered. The filtrate was concentrated and then cooled in an ice bath, in the course of which a solid precipitated out. This was removed by means of a blue-band filter and then dried. The crude product (23.22 g) was recrystallized from 70 ml of ethanol. 17.20 g (58% of theory) of colorless microcrystals having an m.p. of 61-62° C. (lit. 62° C.) were obtained.

Quelle