Reaktion #1747855

Reaktionsgleichung

3,7-dibromo-10-methylphenothiazine

1-naphthylboronic acid

potassium carbonate

methanol

→

10-methyl-3,7-bis(1-naphthyl)phenothiazine

Lösungsmittel

dimethoxyethane

water

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   WaschenThe residue was washed with 470 ml of ethanol and hot water
3. 3
   Sonstigedried at 70° C. under reduced pressure
4. 4
   workup.DISSOLUTIONThe solid was dissolved in 100 ml of methylene chloride
5. 5
   Filtrationfiltered through silica gel
6. 6
   SonstigeAfter the solvent had been removed under reduced pressure
7. 7
   Sonstigea tacky mass was obtained which
8. 8
   Sonstigecrystallized
9. 9
   workup.STIRRINGwith stirring overnight
10. 10
    FiltrationThe crystals were filtered off with suction
11. 11
    Waschenwashed with 300 ml of methanol
12. 12
    Sonstigedried at 40° C. under reduced pressure
13. 13
    Sonstigewere obtained
14. 14
    SonstigeThe crude product was recrystallized twice from ethyl acetate
15. 15
    Sonstigewere obtained

Vorschrift

9.30 g (25.1 mmol) of 3,7-dibromo-10-methylphenothiazine, 9.50 g (55.2 mmol) of 1-naphthylboronic acid, 0.407 g (0.50 mmol) of bis(triphenylphosphane)palladium dichloride and 3.80 g (27.5 mmol) of potassium carbonate were heated to boiling under reflux under nitrogen for 5 hours in 204 ml of dimethoxyethane and 101 ml of water. The reaction mixture was cooled to room temperature, stirred further overnight and then filtered. The residue was washed with 470 ml of ethanol and hot water, and dried at 70° C. under reduced pressure. The solid was dissolved in 100 ml of methylene chloride and filtered through silica gel. After the solvent had been removed under reduced pressure, a tacky mass was obtained which, after 200 ml of methanol had been added, crystallized with stirring overnight. The crystals were filtered off with suction, washed with 300 ml of methanol and dried at 40° C. under reduced pressure. 10.33 g of light yellow microcrystals having a melting point of 185-190° C. were obtained. The crude product was recrystallized twice from ethyl acetate. 5.71 g (49% of theory) of analytically pure, almost colorless microcrystals having a melting point of 191-194° C. were obtained, whose solution in chloroform fluoresced at λ=468 nm.

Quelle