Reaktion #1747352

ord-24604c1bd2a448998fe4932dc3aa00c7

Reaktionsgleichung

Cc1ccccc1-n1cc(C#N)c(=O)[nH]c1=O
5-cyano-1-(2-methylphenyl)uracil
[Na]
sodium
FC(Cl)(Cl)C(Cl)(Cl)SCl
2-fluoro-1, 1,2,2-tetrachloroethanesulphenyl chloride
Cc1cccc(C)c1-n1cc(C#N)c(=O)[nH]c1=O
5-cyano-1-(2,6-dimethylphenyl)uracil
→
Cc1cccc(C)c1-n1cc(C#N)c(=O)n(SC(Cl)(Cl)C(F)(Cl)Cl)c1=O
5-cyano-1-(2,6-dimethylphenyl)-3-(2-fluoro-1,1,2,2-tetrachloroethanesulphenyl)uracil
Cc1ccccc1-n1cc(C#N)c(=O)n(SC(Cl)(Cl)C(F)(Cl)Cl)c1=O
5-cyano-1-(2-methylphenyl)-3-(2-fluoro-1,1,2,2-tetrachloroethanesulphenyl)uracil

Edukte

Cc1ccccc1-n1cc(C#N)c(=O)[nH]c1=O
5-cyano-1-(2-methylphenyl)uracil
[Na]
sodium
FC(Cl)(Cl)C(Cl)(Cl)SCl
2-fluoro-1, 1,2,2-tetrachloroethanesulphenyl chloride
Cc1cccc(C)c1-n1cc(C#N)c(=O)[nH]c1=O
5-cyano-1-(2,6-dimethylphenyl)uracil

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure of Example 5, the sodium salt of 5-cyano-1-(2,6-dimethylphenyl)uracil and 5-cyano-1-(2-methylphenyl)uracil is each reacted with 2-fluoro-1, 1,2,2-tetrachloroethanesulphenyl chloride to yield 5-cyano-1-(2,6-dimethylphenyl)-3-(2-fluoro-1,1,2,2-tetrachloroethanesulphenyl)uracil and 5-cyano-1-(2-methylphenyl)-3-(2-fluoro-1,1,2,2-tetrachloroethanesulphenyl)uracil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04307098uspto-grants-1981_12