Reaktion #1741997

Reaktionsgleichung

4-fluorophenylacetonitrile

HCl

ethanol

→

Ethyl 4-fluorophenylacetimidate hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated in vacuo
2. 2
   Sonstigethe residual oil triturated with ether
3. 3
   FiltrationThe solid was filtered off
4. 4
   Waschenwashed with ether
5. 5
   Sonstigedried (67 g, 83%)
6. 6
   Sonstigeused in subsequent steps without further purification

Vorschrift

A solution of 4-fluorophenylacetonitrile (50 g, 0.37 mol) in absolute ethanol (300 ml) was treated with dry HCl gas with ice cooling for 1 hour. The solvent was evaporated in vacuo, and the residual oil triturated with ether. The solid was filtered off, washed with ether and dried (67 g, 83%), then used in subsequent steps without further purification.

Quelle