Reaktion #1741263

ord-15983ea33e2747b399028b0adbd06381

Reaktionsgleichung

Cc1ccc(O)cc1N
3-amino-4-methylphenol
O=[N+]([O-])c1cccc(S(=O)(=O)[O-])c1.[Na+]
sodium m-nitrobezene sulfonate
O=S(=O)(O)O
sulfuric acid
→
Cc1ccc(O)c2cccnc12
5-hydroxy-8-methylquinoline
Ausbeute 5.8%

Edukte

Cc1ccc(O)cc1N
3-amino-4-methylphenol
O=[N+]([O-])c1cccc(S(=O)(=O)[O-])c1.[Na+]
sodium m-nitrobezene sulfonate
O=S(=O)(O)O
sulfuric acid

Reagenzien

Keine

Lösungsmittel

OCC(O)CO
glycerol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeas in Example 23-(a), reaction and treatment

Vorschrift

Following the same procedure as in Example 23-(a), reaction and treatment were carried out using 3.9 g of 3-amino-4-methylphenol, 7 ml of glycerol, 8.7 g of sodium m-nitrobezene sulfonate and 29 ml of a 80% aqueous sulfuric acid solution in order to obtain 290 mg of 5-hydroxy-8-methylquinoline.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05405843uspto-grants-1995_04