Reaktion #1733563

Reaktionsgleichung

6-chloro-acetyl-3,4-dihydro-2(1H)-quinolinone

ethoxythiocarbonylhydrazine

acetonitrile

→

6-(3,6-dihydro-2-oxo-2H-1,3,4-thiadiazin-5-yl)-3,4-dihydro-2(1H)-quinolinone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   Filtrationfiltered off
3. 3
   SonstigeThe filtrate was recrystallized from dimethylformamide (30 ml) and water (10 ml)

Vorschrift

To a solution of acetonitrile (100 ml) were added 6-chloro-acetyl-3,4-dihydro-2(1H)-quinolinone (6.7 g) and ethoxythiocarbonylhydrazine (5.4 g) and the mixture was stirred for 2 hours, cooled and then filtered off. The filtrate was recrystallized from dimethylformamide (30 ml) and water (10 ml) to obtain pale yellow 6-(3,6-dihydro-2-oxo-2H-1,3,4-thiadiazin-5-yl)-3,4-dihydro-2(1H)-quinolinone (5.2 g), melting at 271°-272° C. (decomposition).

Quelle