Reaktion #1733095

Reaktionsgleichung

1-hydroxyisoquinoline

bromine

→

desired product

Ausbeute 63.4%

4-Bromo-1-isoquinolinol

Ausbeute 63.4%

Lösungsmittel

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe solid was filtered
2. 2
   Waschenwashed with methylene chloride
3. 3
   SonstigeThis solid was recrystallized from ethanol

Vorschrift

To a suspension of 5.0 g (34.5 mmol) of 1-hydroxyisoquinoline in 100 ml of methylene chloride was added 6.0 g (37.7 mmol) of bromine in 20 ml of methylene chloride. The mixture was stirred for four hours, the solid was filtered and washed with methylene chloride. This solid was recrystallized from ethanol to give 4.9 g (63%) of the desired product; mp 245°-250° (dec).

Quelle