Reaktion #1729631

Reaktionsgleichung

Intermediate 15

7-Methyl-6-[4-(trifluoromethoxy)phenyl]-5H-[1,3]thiazolo[3,2-a]-pyrimidin-5-one

2-cyclopropylmethoxy-3-methoxybenzaldehyde

sodium ethoxide

→

desired product

Ausbeute 47.4%

7-{(E)-2-[2-(Cyclopropylmethoxy)-3-methoxyphenyl}-1-ethenyl]-6-(4-trifluoro methoxyphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

Ausbeute 47.4%

Lösungsmittel

ethanol

Reaktionsbedingungen

Vorschrift

The title compound was prepared by condensation of Intermediate 15 (370 mg, 1.132 mmol) with 2-cyclopropylmethoxy-3-methoxybenzaldehyde (327 mg, 1.583 mmol) and sodium ethoxide (154 mg, 2.264 mmol) in ethanol (15 ml) according to the procedure described in Example 24 to afford 276 mg of the desired product as a light yellow solid; 1H NMR (300 MHz, CDCl3) δ 0.30-0.34 (m, 2H), 0.54-0.60 (m, 2H), 1.17-1.24 (m, 1H), 3.79 (d, J=7.2 Hz, 2H), 3.84 (s, 3H), 6.84-6.87 (m, 1H) 6.96-7.00 (m, 4H) 7.31 (d, J=8.4 Hz, 2H), 7.44 (d, J=8.7 Hz, 2H), 7.96 (d, J=4.8 Hz), 8.33 (d, J=15.6 Hz, 1H); ESI-MS (m/z) 515.18 (M+H)+.

Quelle