Reaktion #1728530

Reaktionsgleichung

potassium phthalimide

methyl 4-chloro-3-methoxy-but-2-enoate

water

→

product

methyl(Z)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methoxy-but-2-enoate

Lösungsmittel

DMF

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe precipitate formed
2. 2
   Filtrationfiltered
3. 3
   Waschenwashed with water
4. 4
   workup.DISSOLUTIONThe residue is dissolved in ethyl acetate
5. 5
   Sonstigedried
6. 6
   Sonstigethe solution is evaporated to dryness
7. 7
   SonstigeThe residue is triturated with ether

Vorschrift

18.5 potassium phthalimide are suspended in 50 ml DMF, the mixture is heated to 60° C. and 16.5 g methyl 4-chloro-3-methoxy-but-2-enoate in 50 ml DMF are added. After 2 days the reaction mixture is poured into 500 ml of water. The precipitate formed is suction filtered and washed with water. The residue is dissolved in ethyl acetate, dried and the solution is evaporated to dryness. The residue is triturated with ether. 21.77 g of the product are obtained as a powder.

Quelle