Reaktion #1727315

Reaktionsgleichung

tert-butyl 4-{2-[2-nitro-4-(trifluoromethyl)phenoxy]ethyl}piperazine-1-carboxylate

→

tert-butyl 4-{2-[2-amino-4-(trifluoromethyl)phenoxy]ethyl}piperazine-1-carboxylate

Ausbeute 72.2%

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through Celite
2. 2
   EinengenThe filtrate was concentrated

Vorschrift

Into a 1-neck round-bottom flask was added tert-butyl 4-{2-[2-nitro-4-(trifluoromethyl)phenoxy]ethyl}piperazine-1-carboxylate (2.44 g, 0.0058 mol), 5% palladium/carbon (0.20 g), and EtOAc (74 mL). The mixture was allowed to stir under an atmosphere of hydrogen overnight and then filtered through Celite. The filtrate was concentrated to give tert-butyl 4-{2-[2-amino-4-(trifluoromethyl)phenoxy]ethyl}piperazine-1-carboxylate (1.63 g, 68%) as a white solid. LCMS: (FA) ES+390.1.

Quelle