Reaktion #1726705

Reaktionsgleichung

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole

phosphoric acid

ammonium hydroxide

→

5-amino-1-(3′-nitrophenyl)-pyrazole

Ausbeute 80.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe organics were extracted three times with diethyl ether (total 40 ml)
2. 2
   Waschenwashed with brine
3. 3
   Trocknendried over magnesium sulfate
4. 4
   SonstigeRemoval of solvent

Vorschrift

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole (559 mg, 2.44 mmol) and phosphoric acid (86%, 6 ml) were refluxed at 170° C. for 15 h. The reaction was cooled to room temperature and neutralized with ammonium hydroxide. The organics were extracted three times with diethyl ether (total 40 ml), washed with brine, and dried over magnesium sulfate. Removal of solvent gave 5-amino-1-(3′-nitrophenyl)-pyrazole as a yellow powder (398 mg, 80% yield).

Quelle