Reaktion #1726699

Reaktionsgleichung

5-amino-2-(methylsulfanyl)-4-phenylthiazole

hydrogen peroxide

→

5-amino-2-(methylsulfinyl)-4-phenylthiazole

Ausbeute 87.0%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigedropwise at ambient temperature
2. 2
   SonstigeAfter 4 hr the mixture was partitioned between dichloromethane (60 ml) and water (60 ml)
3. 3
   SonstigeThe organic phase was separated
4. 4
   Waschenwashed with brine
5. 5
   Trocknendried over sodium sulfate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated in vacuo

Vorschrift

To 5-amino-2-(methylsulfanyl)-4-phenylthiazole (305 mg, 1.37 mmol) in acetic acid (3.0 ml) was added aqueous hydrogen peroxide (660 μl, 30% wt, 6.9 mmol) dropwise at ambient temperature. After 4 hr the mixture was partitioned between dichloromethane (60 ml) and water (60 ml). The organic phase was separated, washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo. Flash chromatography on silica gel (ethyl acetate/hexanes) yielded pure 5-amino-2-(methylsulfinyl)-4-phenylthiazole (285 mg, 87%).

Quelle