Reaktion #1723965

ord-65e6cf31619548a2a8b6e6f25f1276a9

Reaktionsgleichung

O=S(=O)(Cl)c1cc2nc(Cl)ccc2s1
5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride
Cl.N#Cc1cc(CN2CC[C@H](N)C2=O)cs1
4-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2-carbonitrile hydrochloride
→
N#Cc1cc(CN2CC[C@H](NS(=O)(=O)c3cc4nc(Cl)ccc4s3)C2=O)cs1
title compound
N#Cc1cc(CN2CC[C@H](NS(=O)(=O)c3cc4nc(Cl)ccc4s3)C2=O)cs1
5-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

Edukte

O=S(=O)(Cl)c1cc2nc(Cl)ccc2s1
5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride
Cl.N#Cc1cc(CN2CC[C@H](N)C2=O)cs1
4-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2-carbonitrile hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product is triturated with Et2O/CH2Cl2 /hexanes
  2. 2
    Sonstigeto give a white solid

Vorschrift

The title compound is prepared from 4-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2-carbonitrile hydrochloride as described in EXAMPLE 1, Part E using 5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride in place of benzo[b]thiophene-2-sulfonyl chloride. The product is triturated with Et2O/CH2Cl2 /hexanes to give a white solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06034093uspto-grants-2000_03