Reaktion #172375

Reaktionsgleichung

hydrochloric acid

hexamethyldisilane

chlorotrimethylsilane

2-hydroxynicotinic acid

diisobutylaluminium hydride

→

3-(Hydroxymethyl)pyridin-2(1H)-one

desired compound

Lösungsmittel

toluene

methanol

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is then cooled to −40° C.
2. 2
   Sonstigeis thawed to RT
3. 3
   workup.STIRRINGstirred at RT for 18 h
4. 4
   Sonstigeat −10° C.
5. 5
   workup.ADDITIONare added such that the temperature
6. 6
   Sonstigedoes not exceed −10° C
7. 7
   SonstigeThe precipitate formed
8. 8
   Filtrationis filtered off
9. 9
   workup.ADDITION100 ml of water are added to the filtrate
10. 10
    workup.STIRRINGthe mixture is stirred at 50° C. for 1 h
11. 11
    Filtrationthe precipitate is filtered off

Vorschrift

At RT, 23.2 g (144 mmol) of hexamethyldisilane and 0.781 g (7.19 mmol) of chlorotrimethylsilane are added to a suspension of 10.0 g (71.9 mmol) of 2-hydroxynicotinic acid in 100 ml of toluene, and the mixture is stirred with a KPG stirrer at 110° C. for 30 min. The mixture is then cooled to −40° C., and 22.5 g (158 mmol) of a 1 molar solution of diisobutylaluminium hydride in dichloromethane are added dropwise to the solution. The mixture is thawed to RT, stirred at RT for 18 h and finally, at −10° C., adjusted to pH=4 with dilute hydrochloric acid, and 500 ml of methanol are added such that the temperature does not exceed −10° C. The precipitate formed is filtered off, 100 ml of water are added to the filtrate, the mixture is stirred at 50° C. for 1 h and the precipitate is filtered off. Concentration of the filtrate gives 8.55 g (95% of theory) of the desired compound.

Quelle