Reaktion #1722947

Reaktionsgleichung

2-amino-4,6-dichloropyrimidine

hexylamine

reagent A

hexylamine

→

expected compound

Ausbeute 62.0%

2-amino-4-hexylamino-6-chloropyrimidine

Ausbeute 62.0%

Lösungsmittel

ethanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 3 h
2. 2
   SonstigeThe medium was evaporated under vacuum
3. 3
   SonstigeThe oil obtained
4. 4
   FiltrationThe precipitate was filtered off
5. 5
   Waschenwashed
6. 6
   Sonstigedried in a heated desiccator

Vorschrift

50 g of 2-amino-4,6-dichloropyrimidine were suspended in 350 ml of absolute ethanol in a reactor. 181.5 ml of hexylamine (reagent A) were added in a single portion and the mixture was refluxed for 3 h. The medium was evaporated under vacuum. The oil obtained was taken up in 600 ml of water with stirring for 1 h, 30 min. The precipitate was filtered off, washed and dried in a heated desiccator. 43.5 g of the expected compound were thus obtained, for a yield of 62%.

Quelle