Reaktion #1722279

ord-9f993c375e924b86a905a615e342518c

Reaktionsgleichung

CCOC(=O)c1cc(C2CC2)c2c(OC)c(Cl)ccn2c1=O
Ethyl-8-chloro-1-cyclopropyl-9-methoxy-4-oxo-4H-quinolizine-3-carboxylate
CC(C)(C)OC(=O)NCCC1CCNC1
3-(N-boc-aminoethyl)pyrrolidine
→
COc1c(N2CCC(CCN)C2)ccn2c(=O)c(C(=O)O)cc(C3CC3)c12
8-[3-aminoethyl-pyrrolidinyl]-1-cyclopropyl-9-methoxy-4-oxo-4H-quinolizine-3-carboxylic acid

Edukte

CCOC(=O)c1cc(C2CC2)c2c(OC)c(Cl)ccn2c1=O
Ethyl-8-chloro-1-cyclopropyl-9-methoxy-4-oxo-4H-quinolizine-3-carboxylate
CC(C)(C)OC(=O)NCCC1CCNC1
3-(N-boc-aminoethyl)pyrrolidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

A series of procedures similar to Example 1 above is carried out, using Ethyl-8-chloro-1-cyclopropyl-9-methoxy-4-oxo-4H-quinolizine-3-carboxylate (Precursor B) and 3-(N-boc-aminoethyl)pyrrolidine (Precursor D) as the starting materials.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06509349B1uspto-grants-2003_01