Reaktion #1722270

Reaktionsgleichung

4-Chloro-3-methoxy-2-methyl-pyridine

N-bromo-succinimide

benzoyl peroxide

→

4-Chloro-3-methoxy-2-bromomethyl-pyridine

Lösungsmittel

carbon tetrachloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is refluxed under UV irradiation for 1.5 hour
2. 2
   FiltrationThe solid is filtered
3. 3
   Temperaturafter cooling
4. 4
   Sonstigethe solvent evaporated
5. 5
   SonstigeThe desired product is purified by chromatography on silica gel

Vorschrift

4-Chloro-3-methoxy-2-methyl-pyridine (6.12 g) is dissolved in carbon tetrachloride (80 ml) then N-bromo-succinimide (7.12 g) and benzoyl peroxide (1 g) are added. The reaction mixture is refluxed under UV irradiation for 1.5 hour. The solid is filtered after cooling and the solvent evaporated. The desired product is purified by chromatography on silica gel.

Quelle