Reaktion #172126

Reaktionsgleichung

product

Methyl 3-bromobenzo[b]thiophene-2-carboxylate

acrylonitrile

tri-tert-butylphosphine

N-methyldicyclohexylamine

→

title compound

(E)-Methyl 3-(2-cyanovinyl)benzo[b]thiophene-2-carboxylate

Lösungsmittel

1,4-dioxane

toluene

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a flask under nitrogen was placed
2. 2
   Temperaturcooled
3. 3
   workup.STIRRINGstirred for 15 minutes
4. 4
   FiltrationThe mixture was filtered
5. 5
   Waschenthe precipitate washed with 25 mL of ethyl acetate
6. 6
   EinengenThe filtrate was concentrated

Vorschrift

In a flask under nitrogen was placed tris(dibenzylideneacetone)dipalladium(0) (313 mg, 0.34 mmol) in 25 mL of 1,4-dioxane followed by the product obtained from Example 97A (4.5 g, 16.7 mmol), N-methyldicyclohexylamine (3.91 g, 20.0 mmol), tri-tert-butylphosphine (0.68 mL of a 1.0 M solution in toluene, 0.68 mmol) and acrylonitrile (1.06 g, 20.0 mmol). The mixture was stirred and heated at 50° C. under nitrogen for 90 minutes and then cooled and diluted with 100 mL of ethyl acetate and stirred for 15 minutes. The mixture was filtered and the precipitate washed with 25 mL of ethyl acetate. The filtrate was concentrated and worked up as described in Example 55B to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 3.92 (s, 3H) 6.55 (d, J=17.29 Hz, 1H) 7.54-7.66 (m, 2H) 8.13-8.25 (m, 3H).

Quelle