Reaktion #172100

Reaktionsgleichung

NH4OH

N-Boc-1-amino-1-cyclopentane carboxylic acid

HOBt hydrate

EDC

→

tert-butyl 1-carbamoylcyclopentylcarbamate

Ausbeute 59.1%

Lösungsmittel

DMF

EtOAc

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred for 18 h
2. 2
   WaschenThe organic phase was washed with 5% NaHCO3
3. 3
   Trocknendried over Na2SO4
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a solution of N-Boc-1-amino-1-cyclopentane carboxylic acid (518 mg, 2.26 mmol) and HOBt hydrate (416 mg, 2.71 mmol) in DMF (5 mL), EDC (522 mg, 2.71 mmol) was added. After being stirred at room temperature for 1 h, conc. NH4OH (14 N, 0.900 mL, 12.6 mmol) was added. The mixture was stirred for 18 h. Water and EtOAc were added. The organic phase was washed with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give tert-butyl 1-carbamoylcyclopentylcarbamate (305 mg).

Quelle