Reaktion #171983

Reaktionsgleichung

4-nitro-1H-pyrazole

iodomethane

NaH

Water

→

1-methyl-4-nitro-1H-pyrazole

Ausbeute 87.3%

Lösungsmittel

DMF

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic phase was separated
2. 2
   Waschenwashed with water
3. 3
   Trocknendried over Na2SO4
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a solution of 4-nitro-1H-pyrazole (1.13 g, 10.0 mmol) and iodomethane (1.25 mL, 20.0 mmol) in DMF (12 mL), NaH (60% in mineral oil, 0.600 g, 15.0 mmol) was added. The mixture was stirred for 18 h. Water and EtOAc were added. The organic phase was separated, washed with water, dried over Na2SO4, concentrated in vacuo to give 1-methyl-4-nitro-1H-pyrazole as a solid (1.11 g).

Quelle