Reaktion #171920

Reaktionsgleichung

2-Amino-1-(1,1-dioxo-llambda*6*-thiomorpholin-4-yl)-propan-1-one

→

(S)-2-(1,1-Dioxo-llambda*6*-thiomorpholin-4-yl)-1-methyl-ethylamine

Ausbeute 128.6%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturto reflux for 48 h
3. 3
   Sonstigequenched by MeOH
4. 4
   SonstigeThe volatile was removed under vacuum
5. 5
   workup.ADDITION2 N HCl (100 mL) was added to the residue
6. 6
   Temperaturheated
7. 7
   Temperaturto reflux for 18 h
8. 8
   SonstigeSolvent was removed under vacuum

Vorschrift

A mixture of 2-Amino-1-(1,1-dioxo-llambda*6*-thiomorpholin-4-yl)-propan-1-one (6.0 g, 18.2 mmol) and BH3 (1 M in THF, 110 mL) was heated to reflux for 48 h, then cooled to room temperature and quenched by MeOH. The volatile was removed under vacuum. 2 N HCl (100 mL) was added to the residue and heated to reflux for 18 h. Solvent was removed under vacuum to give (S)-2-(1,1-Dioxo-llambda*6*-thiomorpholin-4-yl)-1-methyl-ethylamine (4.5 g) as white solid, yield 90%. MS (M+H)=193.

Quelle