Reaktion #1715385

Reaktionsgleichung

(S)-tert-butyl 1-oxo-3-phenyl-1-(3-(pyridin-4-yl)isoxazol-5-ylamino)propan-2-ylcarbamate

TFA

→

(S)-2-amino-3-phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)propanamide

Ausbeute 81.1%

(S)-2-Amino-3-phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)propanamide

Ausbeute 81.1%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas removed with a stream of nitrogen
2. 2
   SonstigeThe crude material was then partitioned between 200 ml of DCM and 100 ml of saturated sodium bicarbonate
3. 3
   SonstigeThe organic solvent was removed by rotary evaporation

Vorschrift

To a 25 ml flask was added (S)-tert-butyl 1-oxo-3-phenyl-1-(3-(pyridin-4-yl)isoxazol-5-ylamino)propan-2-ylcarbamate 3.3B (160 mg, 0.40 mmoles), 10 ml of CH2Cl2, and 5 ml of TFA. The reaction was stirred at room temperature for 3 hour at which time the solvent was removed with a stream of nitrogen. The crude material was then partitioned between 200 ml of DCM and 100 ml of saturated sodium bicarbonate. The organic solvent was removed by rotary evaporation to give (S)-2-amino-3-phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)propanamide 3.3.C as a light yellow solid (100 mg, 81% yield).

Quelle