Reaktion #1715384

Reaktionsgleichung

(S)-tert-butyl 3-(4-fluorophenyl)-1-oxo-1-(3-(pyridin-4-yl)isoxazol-5-ylamino)propan-2-ylcarbamate TFA salt

(S)-tert-butyl 3-(4-fluorophenyl)-1-oxo-1-(3-(pyridin-4-yl)isoxazol-5-ylamino)propan-2-ylcarbamate TFA

TFA

→

(S)-2-amino-3-(4-fluorophenyl)-N-(3-(pyridin-4-yl)isoxazol-5-yl)propanamide diTFA salt

Ausbeute 74.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a 100 ml flask was
2. 2
   Sonstigewas removed

Vorschrift

To a 100 ml flask was (S)-tert-butyl 3-(4-fluorophenyl)-1-oxo-1-(3-(pyridin-4-yl)isoxazol-5-ylamino)propan-2-ylcarbamate TFA salt 3.2.B (620 mg, 0.54 mmole), 10 ml of CH2Cl2, and 10 ml of TFA. The reaction was stirred at room temperature for 4 hours at which time the solvent was removed to give (S)-2-amino-3-(4-fluorophenyl)-N-(3-(pyridin-4-yl)isoxazol-5-yl)propanamide diTFA salt 3.2.C as a light yellow solid (600 mg, 74% yield).

Quelle