Reaktion #1713662

Reaktionsgleichung

2-chloro-6-(trifluoromethyl)nicotinaldehyde

dimethylamine

→

desired compound

Ausbeute 41.8%

2-(dimethylamino)-6-(trifluoromethyl)nicotinaldehyde

Ausbeute 41.8%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Wascheneluted with 5% ethyl acetate/hexanes to 50% ethyl acetate/hexanes

Vorschrift

To a stirred solution of 2-chloro-6-(trifluoromethyl)nicotinaldehyde (115 mg, 0.549 mmol) in THF (1 mL) was added dimethylamine (823 μl, 1.65 mmol). The reaction was heated to 50° C. and stirred for 3 hours. The reaction was loaded onto silica gel and eluted with 5% ethyl acetate/hexanes to 50% ethyl acetate/hexanes to yield the desired compound (50 mg, 0.229 mmol, 41.8% yield).

Quelle