Reaktion #171003

Reaktionsgleichung

6-[4-(6-Benzyloxyhexanoylamino)-phenoxy]-hexanoic acid methyl ester

→

62

Ausbeute 62.8%

6-[4-(6-Hydroxyhexanoylamino)-phenoxy]-hexanoic acid methyl ester

Ausbeute 62.8%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalyst was removed by filtration, and methanol
2. 2
   workup.DISTILLATIONdistilled off
3. 3
   SonstigeCrude 62 was purified by column chromatography on silica gel

Vorschrift

6-[4-(6-Benzyloxyhexanoylamino)-phenoxy]-hexanoic acid methyl ester 61 (10 g, 22.67 mmol) was dissolved in methanol (100 ml) in a pressure vessel. Palladium on carbon (5%, 6 grm) was added and the mixture stirred under a hydrogen atmosphere (4 kg) for 20 hrs. The catalyst was removed by filtration, and methanol distilled off. Crude 62 was purified by column chromatography on silica gel using chloroform as eluant to give pure 62 (5 g, 62.8%) as a white powder with a m.p. between 73-75.5° C.

Quelle