Reaktion #170992

Reaktionsgleichung

[2-(4-Nitrophenoxy)ethoxy]acetic acid methyl ester

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester

→

43

Ausbeute 71.1%

[2-(4-Aminophenoxy)-ethoxy]-acetic acid methyl ester

Ausbeute 71.1%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefor 30 mins
2. 2
   FiltrationThe cat-alyst was filtered
3. 3
   Einengenthe filtrate concentrated
4. 4
   workup.ADDITIONhexane (3 ml) added
5. 5
   Filtrationthe solid filtered

Vorschrift

[2-(4-Nitrophenoxy)ethoxy]acetic acid methyl ester 42 (1 g, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 ml). Palladium on carbon (10%, 0.1 g) was added and the mixture stirred under a hydrogen atmosphere using a balloon for 30 mins. The cat-alyst was filtered, the filtrate concentrated, hexane (3 ml) added, and the solid filtered to give 43 (625 mg, 70.9%) as a light brown powder with a m.p. between 51-52.5° C.

Quelle