Reaktion #170956

ord-9069b2e2cf384531903fee23e517008c

Reaktionsgleichung

Cl
Hydrochloric acid
CCOC(=O)COc1ccc(NC(C)=O)cc1
(4-Acetylamino-phenoxy)-acetic acid ethyl ester
→
Cl.Nc1ccc(OCC(=O)O)cc1
2
Ausbeute 77.6%
Cl.Nc1ccc(OCC(=O)O)cc1
(4-Amino-phenoxy)acetic acid HCl
Ausbeute 77.6%

Edukte

Cl
Hydrochloric acid
CCOC(=O)COc1ccc(NC(C)=O)cc1
(4-Acetylamino-phenoxy)-acetic acid ethyl ester

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
10°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.DISTILLATIONExcess concentrated Hydrochloric acid was distilled off in vacuum
  2. 2
    Filtrationfiltered hot
  3. 3
    Filtrationfiltered
  4. 4
    Sonstigedried

Vorschrift

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2 (250 g, 77.6%) as a wheat colored powder.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08846845B2uspto-grants-2014_09