Reaktion #170765

Reaktionsgleichung

1-(1-methoxycarbonylvinyl)cyclopropanecarboxylic acid methyl ester

2,4-dimethoxybenzylamine

→

titled compound

5-(2,4-Dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic acid methyl ester

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 20 hours
2. 2
   EinengenThis reaction mixture was concentrated under reduced pressure
3. 3
   Sonstigethe resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1)

Vorschrift

To a solution of 1-(1-methoxycarbonylvinyl)cyclopropanecarboxylic acid methyl ester (720 mg) in toluene (3.6 ml) was added 2,4-dimethoxybenzylamine (587 μl) at room temperature, and then the mixture was stirred at reflux for 20 hours. This reaction mixture was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1) to give the titled compound (567 mg).

Quelle