Reaktion #1705906

Reaktionsgleichung

morpholine

tert-butyl 7-chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-1-carboxylate

XPhos

sodium ter-butoxide

→

tert-butyl 7-morpholino-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-1-carboxylate

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePrepared
2. 2
   Sonstigeat 100° C.
3. 3
   Sonstigefor 14 h
4. 4
   SonstigePurification by column chromatography (hexanes:EtOAc, 1:0 to 1:1)

Vorschrift

Prepared according to procedure N by using tert-butyl 7-chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-1-carboxylate (340 mg, 1.19 mmol), Pd2dba3 (109 mg, 0.119 mmol), XPhos (113 mg, 0.237 mmol), sodium ter-butoxide (228 mg, 2.371 mmol), morpholine (0.13 mL, 1.54 mmol) in toluene (8 mL) at 100° C. for 14 h. Purification by column chromatography (hexanes:EtOAc, 1:0 to 1:1) gave tert-butyl 7-morpholino-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-1-carboxylate. Mass Spectrum (ESI) m/e=338.2 (M+1).

Quelle