Reaktion #1705082

ord-1142f89cebd24a658f784c1517deebe9

Reaktionsgleichung

COc1ccc(C(C)=O)cn1
5-acetyl-2-methoxypyridine
Cc1ncsc1C=O
4-methylthiazole-5-carbaldehyde
[K+].[OH-]
potassium hydroxide
COc1ccc(C(=O)/C=C/c2scnc2C)cn1
title compound
COc1ccc(C(=O)/C=C/c2scnc2C)cn1
(E)-1-(6-Methoxypyridin-3-yl)-3-(4-methylthiazol-5-yl)prop-2-en-1-one

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 170, step 1, 5-acetyl-2-methoxypyridine was reacted with 4-methylthiazole-5-carbaldehyde in the presence of potassium hydroxide to give the title compound as an off-white solid. MS (ESI+): m/z=261.1 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08765730B2uspto-grants-2014_07