Reaktion #1705052

ord-91b6c48ce9be43e79d8bcb26e15774eb

Reaktionsgleichung

Cn1cc(C(=O)CC(c2cccc(S(C)(=O)=O)c2)c2ccc(Cl)cc2F)ccc1=O
5-(3-(4-chloro-2-fluorophenyl)-3-(3-(methylsulfonyl)-phenyl)propanoyl)-1-methylpyridin-2(1H)-one
Cl.NO
hydroxylamine hydrochloride
O=C([O-])O.[Na+]
sodium hydrogencarbonate
→
Cn1cc(/C(CC(c2cccc(S(C)(=O)=O)c2)c2ccc(Cl)cc2F)=N/O)ccc1=O
title compound
Cn1cc(/C(CC(c2cccc(S(C)(=O)=O)c2)c2ccc(Cl)cc2F)=N/O)ccc1=O
(E)-5-(3-(4-Chloro-2-fluorophenyl)-1-(hydroxyimino)-3-(3-(methylsulfonyl)phenyl)-propyl)-1-methylpyridin-2(1H)-one

Edukte

Cn1cc(C(=O)CC(c2cccc(S(C)(=O)=O)c2)c2ccc(Cl)cc2F)ccc1=O
5-(3-(4-chloro-2-fluorophenyl)-3-(3-(methylsulfonyl)-phenyl)propanoyl)-1-methylpyridin-2(1H)-one
Cl.NO
hydroxylamine hydrochloride
O=C([O-])O.[Na+]
sodium hydrogencarbonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 151, step 3, 5-(3-(4-chloro-2-fluorophenyl)-3-(3-(methylsulfonyl)-phenyl)propanoyl)-1-methylpyridin-2(1H)-one was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound as a colourless solid, MS (ESI+): m/z=463.1 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08765730B2uspto-grants-2014_07